Endocrine Abstracts

Expression of the mt1 melatonin receptor has been described in both the pars tuberalis (PT) and pars distalis (PD) of the rat pituitary gland. Expression of mt1 mRNA and iodomelatonin (IMEL) binding sites is high in the neonate PD but rapidly declines over the initial weeks of postnatal life. In contrast, both mt1 mRNA and IMEL binding sites are preserved in the PT through to adulthood, leading to a marked tissue-specific expression profile.To identify ...

We investigated the relationship between gestational diabetes (GDM) and the metabolic syndrome in 368 (185 European (EUR), 103 South Asian (SA) and 80 Afro-Caribbean (AC)) women studied 20.0 (18.2-22.1) months (mean (95% CI)) following a GDM pregnancy and 482 normoglycaemic women (288 EUR, 99 SA, 95 AC) with no history of GDM. Estimates of beta-cell function (%B) and insulin sensitivity (%S) were derived using the HOMA method. Analysis was by multiple linear regression includi...